Understanding how cells recycle their components through selective autophagy
Dissecting the Molecular Mechanisms of Selective Autophagy
This study looks at how cells clean up and recycle their parts to stay healthy, using yeast to learn more about how this process works, which could help us understand and improve treatments for diseases like cancer and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth College NIH-funded |
| Lab location | 1 site (Hanover, United States) |
| Project ID | NIH-10765072 on NIH RePORTER |
What this research studies
This research investigates the process of selective autophagy, where cells capture and degrade specific cellular components to maintain health. By using yeast as a model, the study aims to uncover the mechanisms that enable integral membrane proteins to interact with the autophagy machinery. This could lead to a better understanding of how defects in this process contribute to diseases like cancer and neurodegenerative disorders. Patients may benefit from insights gained into how to enhance or restore autophagy in various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to autophagy defects, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to autophagy or those who do not have any known genetic predisposition to autophagy-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to autophagy dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding autophagy mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Hanover, United States
- Dartmouth College — Hanover, United States (Active)
Researchers
- Principal investigator: Ragusa, Michael Joseph — Dartmouth College
- Study coordinator: Ragusa, Michael Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.