Understanding how cells recycle proteins and lipids
Molecular regulation of endosome fission during endocytic recycling
This study is looking at how tiny structures in our cells, called endosomes, help recycle important materials, and it's using a small worm called C. elegans to learn more about this process, which could help us understand similar functions in human cells and improve our knowledge of health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers, the State Univ of N.j. NIH-funded |
| Lab location | 1 site (Piscataway, United States) |
| Project ID | NIH-10981032 on NIH RePORTER |
What this research studies
This research investigates the process of recycling endosomes, which are crucial for returning proteins and lipids to the cell membrane after they have been internalized. Using the simple model organism C. elegans, the study aims to uncover the mechanisms that regulate the formation and function of these endosomes. The findings will then be applied to mammalian cells to enhance our understanding of these processes in more complex organisms. By focusing on the intestine of C. elegans, researchers can analyze endocytic pathways in a controlled environment, providing insights that may have broader implications for human health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that may be linked to cellular recycling dysfunction, particularly those over 21 years old.
Not a fit: Patients with conditions unrelated to cellular recycling processes or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to cellular recycling processes, potentially impacting various diseases.
How similar studies have performed: Other research has shown success in understanding cellular recycling processes using model organisms, indicating that this approach has potential for meaningful insights.
Where this research is happening
Piscataway, United States
- Rutgers, the State Univ of N.j. — Piscataway, United States (Active)
Researchers
- Principal investigator: Grant, Barth Demian — Rutgers, the State Univ of N.j.
- Study coordinator: Grant, Barth Demian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.