Understanding how cells recycle damaged peroxisomes
Investigating the role of autophagy inducers and peroxisomal proteins in pexophagy
This study is looking at how our cells clean up and recycle damaged parts called peroxisomes, which help keep us healthy by getting rid of harmful substances, and it aims to understand how this process works in both plants and people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rice University NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10899140 on NIH RePORTER |
What this research studies
This research investigates the process of pexophagy, where cells recycle damaged peroxisomes, which are essential for detoxifying harmful substances. By studying the role of specific proteins and autophagy in this process, the research aims to uncover how cells maintain their health and function under stress. The approach involves monitoring the behavior of peroxisomes and autophagosomes using advanced techniques like western blotting and fluorescence microscopy. This could lead to insights into how cellular recycling mechanisms work in both plants and humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to peroxisome dysfunction or those interested in cellular biology and its implications for health.
Not a fit: Patients with conditions unrelated to peroxisome function or those not interested in cellular biology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular health and lead to new strategies for treating diseases related to peroxisome dysfunction.
How similar studies have performed: While the specific focus on pexophagy in humans is relatively novel, similar studies on autophagy have shown promising results in understanding cellular processes.
Where this research is happening
Houston, United States
- Rice University — Houston, United States (Active)
Researchers
- Principal investigator: Jackson, Makaela — Rice University
- Study coordinator: Jackson, Makaela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.