Understanding how cells recognize and maintain DNA during reproduction and immune responses
Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunity
This study is looking at how cells keep track of their DNA during the special type of cell division that creates eggs and sperm, as well as how our immune system works, to help us understand more about DNA and its role in diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11240454 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that allow cells to recognize and maintain DNA during meiosis, the process of cell division that produces gametes, and in innate immunity. The approach involves studying the structure and function of proteins that interact with DNA, particularly focusing on the meiotic chromosome axis and its role in ensuring accurate DNA segregation. By examining these interactions, the research aims to uncover fundamental insights into genome maintenance, which could have implications for understanding various diseases, including cancers.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with genetic disorders or cancers related to DNA repair mechanisms.
Not a fit: Patients with conditions unrelated to DNA maintenance or those not affected by genetic instability may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic stability and potential therapeutic strategies for diseases related to DNA damage and repair.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms and their implications in various diseases, indicating that this approach is built on established scientific foundations.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Corbett, Kevin Daniel — University of California, San Diego
- Study coordinator: Corbett, Kevin Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.