Understanding how cells recognize and maintain DNA during reproduction and immune responses
Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunity
This study is looking at how certain proteins help cells keep track of DNA during the process of making eggs and sperm, as well as how our immune system works, which could help us understand more about diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10999403 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that allow cells to recognize and maintain DNA during meiosis, the process that produces gametes, and in innate immunity. The approach involves studying the structure and function of proteins that interact with DNA, particularly focusing on the chromosome organization and the role of specific ATPase proteins in these processes. By examining how these proteins assemble and function, the research aims to uncover critical insights into genome maintenance and its implications for diseases such as cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or cancers that may be linked to issues in DNA maintenance and repair.
Not a fit: Patients with conditions unrelated to DNA maintenance or those not experiencing genetic instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic stability and potential new therapies for diseases related to DNA damage and repair.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms and their implications for cancer treatment, indicating that this approach is built on established scientific foundations.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Corbett, Kevin Daniel — University of California, San Diego
- Study coordinator: Corbett, Kevin Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.