Understanding how cells protect themselves from low oxygen damage
DEFINING RAPTOR-MEDIATED MECHANISMS OF HYPOXIC INJURY
This project explores how a key cellular pathway helps protect cells from damage when oxygen levels are low, using a tiny worm called C. elegans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11126708 on NIH RePORTER |
What this research studies
Our cells rely on a pathway called mTOR to manage how they use nutrients and energy, which is important for many bodily functions. One part of this pathway, a protein called Raptor, plays a crucial role in how cells respond to stress, including when they don't get enough oxygen. We discovered that reducing the function of Raptor in C. elegans worms makes them more resistant to low oxygen conditions. By studying these worms, we aim to uncover the exact steps and molecules involved in this protective response.
Who could benefit from this research
Good fit: Patients with conditions involving low oxygen damage, such as stroke or heart attack, might indirectly benefit from the future applications of this fundamental research.
Not a fit: Patients seeking immediate treatment options will not directly benefit from this foundational laboratory research.
Why it matters
Potential benefit: This basic understanding could lead to new ways to protect human cells and tissues from damage caused by low oxygen, which occurs in conditions like heart attack or stroke.
How similar studies have performed: This work builds on decades of research into the mTOR pathway, but the specific discovery of Raptor's role in hypoxia resistance in C. elegans is a novel finding.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Crowder, C. Michael — University of Washington
- Study coordinator: Crowder, C. Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.