Understanding how cells protect themselves from age-related amino acid toxicity
Official title: Investigating the Lysosome and Plasma Membrane Systems in Protecting Cells Against Age-induced Amino Acid Toxicity
Funded at University of Utah · NIH-11041042 · Data updated 2026-11-12
This study is looking at how our cells protect themselves from harmful effects of amino acids as we get older, especially in relation to diseases like Alzheimer's and Parkinson's, to find ways to keep our cells healthy and strong as we age.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $39,884 |
| NIH project number | 5F31AG082494-03 |
| Project ID | NIH-11041042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who are at risk for or experiencing symptoms of age-related diseases.
✕Less likely to help
Patients who are younger and do not have any age-related conditions may not receive direct benefits from this research.
What this research studies
This research investigates the cellular mechanisms that help protect against the toxic effects of amino acids as we age, particularly focusing on the lysosome and plasma membrane systems. The study aims to identify key genes that play a role in maintaining cellular health during aging, especially in the context of diseases like Alzheimer's and Parkinson's. By examining how these cellular processes change with age, the research seeks to uncover potential therapeutic targets that could improve cellular function and resilience. Patients may benefit from insights gained about how to mitigate age-related cellular dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases such as Alzheimer's and Parkinson's.
How similar studies have gone: Previous research has shown promising results in understanding cellular aging processes, but this specific approach focusing on lysosomal function in relation to amino acid toxicity is relatively novel.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Chui, Kevin — University of Utah
- Study coordinator: Chui, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.