Understanding how cells protect DNA during stress and its effect on the immune system
Official title: Replication fork protection and innate immune response
Funded at University of Tx Md Anderson Can Ctr · NIH-10980646 · Data updated 2026-11-12
This study looks at how our cells keep their DNA safe when they're under stress, which is important for staying healthy, and it explores how problems with DNA can cause inflammation in the body, helping us understand more about cancer and how our immune system reacts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $340,200 |
| NIH project number | 1R01GM152613-01A1 |
| Project ID | NIH-10980646 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions related to genome instability, such as certain types of cancer or genetic disorders like Fanconi anemia.
✕Less likely to help
Patients with stable genome integrity and no history of cancer or related disorders may not benefit from this research.
What this research studies
This research investigates how cells protect their DNA during stressful conditions that can lead to genome instability, which is crucial for maintaining overall health. It focuses on the relationship between stalled DNA replication forks and the innate immune response, exploring how damaged DNA can trigger inflammation in the body. By studying specific proteins involved in this process, the research aims to uncover the mechanisms that link DNA repair and immune activation. This could provide insights into how certain cancers develop and how the body responds to them.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers by enhancing our understanding of DNA repair mechanisms and their impact on immune responses.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between DNA damage and immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Wang, Bin — University of Tx Md Anderson Can Ctr
- Study coordinator: Wang, Bin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.