Understanding how cells produce energy through mitochondria
Official title: Spatial coordination of cytosolic and mitochondrial translation
Funded at Albert Einstein College of Medicine · NIH-10899596 · Data updated 2026-11-12
This study is looking at how the processes that make energy in our cells work together, focusing on how certain messages from our genes get to the parts of the cell that produce energy, which could help us understand diseases like Alzheimer's and heart problems better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $125,000 |
| NIH project number | 5K99GM148788-02 |
| Project ID | NIH-10899596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are affected by Alzheimer's disease or related conditions.
✕Less likely to help
Patients with non-mitochondrial related disorders or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the coordination between cytosolic and mitochondrial translation processes that are essential for energy production in cells. By using advanced imaging techniques, the study aims to explore how specific mRNAs from both the nuclear and mitochondrial genomes interact and localize within mitochondria. This could provide insights into the fundamental mechanisms of ATP synthase assembly, which is crucial for cellular energy metabolism and may have implications for various diseases, including Alzheimer's and heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to mitochondrial dysfunction.
How similar studies have gone: Previous studies have shown promising results in understanding mitochondrial function and its implications for diseases, indicating that this approach has potential for success.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Li, Weihan — Albert Einstein College of Medicine
- Study coordinator: Li, Weihan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.