Understanding how cells process genetic instructions
Protein RNA Rearrangements in the Spliceosome
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11007253
This project aims to understand how our cells correctly read genetic information, which is important for conditions like Aran-Duchenne disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11007253 on ClinicalTrials.gov |
What this research studies
Our bodies rely on cells to correctly read genetic instructions to make proteins. A key step in this process is called splicing, where a cellular machine called the spliceosome removes unnecessary parts from genetic messages. When the spliceosome doesn't work correctly, it can lead to diseases. This project wants to learn more about how the spliceosome recognizes the right places to cut and how its parts move and interact to ensure accurate genetic instructions are made. We are also looking into a newly discovered molecule, inositol hexakisphosphate (IP6), and its role in this vital process.
Who could benefit from this research
Good fit: This foundational work could eventually benefit patients with conditions linked to errors in how their cells process genetic information.
Not a fit: Patients whose conditions are not related to errors in gene expression or spliceosome function would likely not directly benefit from this specific research.
Why it matters
Potential benefit: A deeper understanding of how the spliceosome works could lead to new ways to address diseases caused by errors in gene expression, such as Aran-Duchenne disease.
How similar studies have performed: This project explores newly discovered aspects of the spliceosome, building on existing knowledge but venturing into previously unexamined mechanisms.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QUERY, CHARLES C — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: QUERY, CHARLES C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aran-Duchenne disease