Understanding how cells orient themselves in tissues
Planar cell polarity mechanisms and systems architecture
This study is looking at how cells work together to stay organized and move in the right direction, using fruit flies to learn more about this process, which could help us understand some growth and health issues in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10841878 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of planar cell polarity (PCP) signaling, which is crucial for the proper orientation and movement of cells within tissues. By using advanced genetic techniques in the model organism Drosophila, the study aims to uncover how cells communicate and coordinate their polarization, which is essential for various developmental processes. The research employs innovative methods such as single molecule imaging and advanced biochemistry to explore these cellular behaviors in detail. The findings could provide insights into developmental defects and physiological processes in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with developmental defects or conditions related to cell signaling and polarization.
Not a fit: Patients with conditions unrelated to cellular signaling or those over 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental defects and improve treatments for related conditions in humans.
How similar studies have performed: Previous research has shown success in understanding cell signaling mechanisms using similar genetic approaches in model organisms.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Axelrod, Jeffrey D. — Stanford University
- Study coordinator: Axelrod, Jeffrey D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.