Understanding how cells organize themselves in tissues
Defining the molecular and cellular bases of tissue compartmentalization
This study is looking at how certain structures in our tissues help keep everything organized as we grow, which is important for preventing issues like birth defects and cancer, and it’s for anyone interested in understanding how our bodies work and how diseases can affect tissue health.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project ID | NIH-10292120 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that help maintain the organization of complex tissues during growth and remodeling by focusing on structures called compartment boundaries. These boundaries are formed by actin-rich structures that separate groups of cells and are crucial for proper tissue function. The study will utilize genetic techniques to manipulate specific proteins involved in boundary formation, aiming to uncover how these structures contribute to the integrity of tissues and their role in conditions like birth defects and cancer. By understanding these processes, the research hopes to provide insights into how tissue organization can be affected in various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital abnormalities or birth defects that may be linked to tissue organization issues.
Not a fit: Patients with conditions unrelated to tissue compartmentalization or those who do not have congenital abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating congenital abnormalities and other related conditions.
How similar studies have performed: Previous research has shown success in understanding cellular organization and its implications in various conditions, making this approach promising.
Where this research is happening
Fayetteville, United States
- University of Arkansas at Fayetteville — Fayetteville, United States (Active)
Researchers
- Principal investigator: Pare, Adam Christopher — University of Arkansas at Fayetteville
- Study coordinator: Pare, Adam Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.