Understanding how cells organize their surfaces without a key protein
Mechanisms of polarized protein sorting in AP-1B-deficient epithelia
This research looks at how our body's cells organize their surfaces to perform important tasks, especially when a specific protein called AP-1B is not present.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-11141100 on NIH RePORTER |
What this research studies
Epithelial cells, which line many parts of our body like the gut and kidneys, have specialized surfaces to absorb nutrients or secrete substances. These cells need to make sure the right tools, called proteins, are on the correct side of their surface to function properly. This project explores how these cells manage to sort and place these proteins accurately, particularly in situations where a protein called AP-1B, which usually helps with this sorting, is missing. By understanding these fundamental processes, we can learn more about diseases where cell organization goes wrong.
Who could benefit from this research
Good fit: This foundational research does not currently involve direct patient participation.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could help us better understand and potentially treat diseases where the organization and function of epithelial cells are disrupted, such as in certain kidney or eye conditions.
How similar studies have performed: This project builds on previous findings about protein sorting mechanisms but explores new pathways in cells lacking AP-1B.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Caceres, Paulo Sebastian — Wayne State University
- Study coordinator: Caceres, Paulo Sebastian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.