Understanding how cells organize their internal structures
Intracellular pattern formation
['FUNDING_R01'] · UNIVERSITY OF GEORGIA · NIH-10813158
This study looks at how tiny structures inside cells, called organelles, are arranged and work together, using a simple organism called Tetrahymena thermophila to learn more about the genes and molecules that help organize these structures, which is important for how cells function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF GEORGIA (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-10813158 on ClinicalTrials.gov |
What this research studies
This research investigates the organization of cytoskeletal organelles within cells, focusing on how these structures form specific patterns that are crucial for cell function. By studying the ciliated protist Tetrahymena thermophila, researchers aim to uncover the genetic and molecular mechanisms that dictate the arrangement of organelles like cilia in epithelial and inner hair cells. The approach involves genetic screening and analysis of mutations that affect organelle positioning, which could lead to insights into cellular behavior and development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions affecting cellular structures or those with diseases related to cilia dysfunction, such as certain types of hearing loss.
Not a fit: Patients with conditions unrelated to cellular organization or those not affected by cilia-related disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular organization, potentially leading to new treatments for conditions related to cell dysfunction.
How similar studies have performed: While the specific approach of this research is novel, previous studies have shown success in understanding cellular patterns and their implications in various diseases.
Where this research is happening
ATHENS, UNITED STATES
- UNIVERSITY OF GEORGIA — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAERTIG, JACEK — UNIVERSITY OF GEORGIA
- Study coordinator: GAERTIG, JACEK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.