Understanding how cells move together to shape tissues and organs
Official title: Molecular and cell biological basis of convergent extension
Funded at University of Texas at Austin · NIH-10990799 · Data updated 2026-11-12
This study is looking at how cells work together to help shape our bodies during development, especially focusing on a system that, if it doesn't work right, can lead to serious birth defects. By using special imaging tools, the researchers hope to understand how signals inside and outside the cells guide their movements, which could help explain some developmental disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $455,596 |
| NIH project number | 2R01HD099191-10 |
| Project ID | NIH-10990799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of neural tube defects or skeletal dysplasias.
✕Less likely to help
Patients with conditions unrelated to tissue development or cell movement may not benefit from this research.
What this research studies
This research investigates the process of convergent extension, a collective cell movement that is crucial for the elongation of tissues and organs in animals. It focuses on the signaling pathways that control this process, particularly the planar cell polarity (PCP) system, which, when disrupted, can lead to serious birth defects. By utilizing advanced imaging techniques and molecular assays, the research aims to clarify how mechanical and molecular signals influence cell behavior during tissue development. This could provide insights into the underlying causes of certain developmental disorders.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of birth defects related to tissue development.
How similar studies have gone: Previous research has shown promising results in understanding cell movement and its implications for developmental disorders, indicating that this approach has potential for success.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Wallingford, John B — University of Texas at Austin
- Study coordinator: Wallingford, John B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.