Understanding how cells move in three-dimensional environments
The mechanisms regulating actin dynamics and polarized membrane transport during cell migration
This study is looking at how certain proteins help cells move through the spaces around them, which is important for both healthy tissue growth and cancer spread, and it uses special imaging tools to see how these proteins work in real-time, with the hope of finding better ways to treat cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10917071 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that control how cells migrate through three-dimensional extracellular matrices, which is crucial for tissue development and cancer progression. By focusing on a specific family of proteins known as Rab40, the study aims to uncover how these proteins regulate cell movement and communication. The research employs advanced imaging techniques to observe cell behavior in real-time, providing insights into the molecular interactions that facilitate migration. This knowledge could lead to new strategies for targeting cancer metastasis and improving treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer or other cancers where cell migration plays a critical role in disease progression.
Not a fit: Patients with non-cancerous conditions or those whose diseases do not involve significant cell migration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in cancer treatment by identifying new targets for therapy that inhibit cancer cell migration.
How similar studies have performed: Previous research has shown success in understanding cell migration mechanisms, but this specific focus on Rab40 proteins represents a novel approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Prekeris, Rytis — University of Colorado Denver
- Study coordinator: Prekeris, Rytis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.