Understanding how cells move in response to signals
Decoding dynamic interplay between signaling and membranes in chemotaxis by molecular actuators
This study is looking at how the signals that tell cells where to go interact with the cell's outer layer, which can change shape and affect movement, and it's aimed at helping us understand important things like healing wounds and how diseases like cancer and arthritis develop.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11229924 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between biochemical signals and the physical properties of cell membranes that influence how cells migrate. By developing advanced molecular tools, the study aims to explore how changes in membrane shape and structure affect cell movement in response to chemical signals. This could provide insights into critical processes such as wound healing and the progression of diseases like cancer and arthritis, ultimately enhancing our understanding of cell behavior in various physiological and pathological contexts.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to abnormal cell migration, such as cancer or arthritis.
Not a fit: Patients with conditions unrelated to cell migration or those not experiencing significant cell signaling issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases characterized by abnormal cell migration, such as cancer metastasis and arthritis.
How similar studies have performed: Previous research has shown promising results in understanding cell migration through biochemical signaling, but this approach focusing on membrane mechanics is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Inoue, Takanari — Johns Hopkins University
- Study coordinator: Inoue, Takanari
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.