Understanding how cells move in diseases like cancer and heart conditions
Official title: Cell mechanoresponses in physiologically relevant microenvironments
Funded at Auburn University at Auburn · NIH-11103326 · Data updated 2026-11-12
This project explores how cells move and react to their environment, hoping to find new ways to prevent and treat diseases like cancer, heart problems, and issues related to aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Auburn University at Auburn NIH-funded |
| Lab location | 1 site (Auburn, UNITED STATES) |
| Project start | August 10, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $373,063 |
| NIH project number | 5R35GM147101-04 |
| Project ID | NIH-11103326 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research does not directly involve patient participation at this stage.
✕Less likely to help
Patients not affected by cancer, cardiovascular pathologies, or aging-related conditions may not directly benefit from this specific research.
What this research studies
Our bodies' cells are constantly moving, a process that's crucial for healthy development but also plays a big role in diseases like cancer spreading or heart conditions developing. This project looks closely at how the physical environment around cells, such as pressure or stiffness, influences their movement and survival. By using advanced tools and simulations, we aim to understand how these physical cues turn into signals inside the cells. The goal is to uncover the fundamental ways cells respond to their surroundings, especially under pressure, which is common in many diseases.
Why it matters
Potential benefit: If successful, this work could lead to new treatments and strategies to stop the progression of diseases like cancer, heart disease, and age-related conditions.
How similar studies have gone: This project builds on previous findings about how cells experience pressure, but it explores new, unanswered questions about how cells behave under different pressures in the body.
Where this research is happening
-
Auburn University at Auburn
Auburn, United States Active
Researchers
- Principal investigator: Mistriotis, Panagiotis — Auburn University at Auburn
- Study coordinator: Mistriotis, Panagiotis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.