Understanding how cells move in curved tissues
Official title: Integrative biophysical modeling for collective tissue mechanics
Funded at Northeastern University · NIH-10908409 · Data updated 2026-11-12
This study looks at how certain types of cells move and behave on curved surfaces, which is important for things like healing and development in our bodies, and it uses computer models to help us understand these processes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northeastern University NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $394,000 |
| NIH project number | 5R35GM150494-02 |
| Project ID | NIH-10908409 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to tissue development or repair, such as congenital disorders or injuries requiring regenerative therapies.
✕Less likely to help
Patients with stable, non-progressive conditions that do not involve tissue remodeling or development may not benefit from this research.
What this research studies
This research investigates the mechanics of how epithelial and endothelial cells behave on curved surfaces, which is crucial for understanding various physiological processes like embryonic development and tissue repair. By using advanced biophysical modeling, the project aims to explore the transition of these cells from a static to a dynamic state, particularly in three-dimensional environments. The approach combines computer modeling with biological insights to better predict how cells interact and move in natural tissue structures. This could lead to improved understanding of tissue mechanics and development.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of tissue development and repair, potentially leading to new therapeutic strategies for various diseases.
How similar studies have gone: While the study of cell behavior in flat surfaces is well-established, this research represents a novel approach by focusing on the complexities of curved tissue environments.
Where this research is happening
-
Northeastern University
Boston, United States Active
Researchers
- Principal investigator: Bi, Dapeng — Northeastern University
- Study coordinator: Bi, Dapeng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.