Understanding how cells move important materials inside themselves
Mechanisms and Physiology of COPI Transport
['FUNDING_R37'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10987065
This research helps us understand the basic ways cells move important materials around inside themselves.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10987065 on ClinicalTrials.gov |
What this research studies
Our cells are constantly moving materials around, much like a tiny delivery system. This project looks closely at a key part of this system called COPI transport, which helps create small packages and tubes within cells. We want to learn how certain proteins, like Cdc42, help shape these packages and tubes, and how other proteins might also play a role. We are also exploring how COPI itself bends cell membranes and how a protein called IFT20 contributes to this process. This foundational work helps us understand the essential machinery that keeps our cells working properly.
Who could benefit from this research
Good fit: This foundational cell biology research does not directly involve patient participation.
Not a fit: Patients seeking immediate treatment options or direct clinical interventions will not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding these fundamental cellular processes could eventually lead to insights into various diseases where cell transport goes wrong.
How similar studies have performed: This project builds upon the researchers' previous discoveries in COPI transport, indicating a track record of success in this specific area.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSU, VICTOR W — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: HSU, VICTOR W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.