Understanding how cells move during development and disease
Coordinated Actin Regulation in Directed Neural Crest Cell Migration
['FUNDING_R01'] · GEORGIA INSTITUTE OF TECHNOLOGY · NIH-10825571
This study is looking at how a special protein called Cdc42ep1 helps control the movement of important cells during development, which could help us understand issues like birth defects and certain cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGIA INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10825571 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms that control the movement of neural crest cells, which are crucial for proper development and can be involved in various diseases. The study focuses on a specific protein, Cdc42ep1, and its interactions with other proteins that regulate cell movement. By using a model organism, the researchers aim to uncover how these proteins work together to ensure efficient cell migration. This knowledge could lead to better understanding of birth defects and cancers related to cell migration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by congenital abnormalities or cancers linked to cell migration issues.
Not a fit: Patients with conditions unrelated to cell migration or those who do not have congenital abnormalities or cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for conditions related to improper cell migration, such as certain birth defects and cancers.
How similar studies have performed: Other research has shown success in understanding cell migration mechanisms, but this specific approach focusing on Cdc42ep1 is relatively novel.
Where this research is happening
ATLANTA, UNITED STATES
- GEORGIA INSTITUTE OF TECHNOLOGY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIE, SHUYI — GEORGIA INSTITUTE OF TECHNOLOGY
- Study coordinator: NIE, SHUYI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer