Understanding how cells move and survive during embryo development
Investigating how sequentially acting cues guide long-distance cell migration in vivo within embryos
This study looks at how certain muscle cells in fruit flies move together during development and how different signals help guide their movement, which could help us understand what goes wrong when these processes lead to health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10883663 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind collective cell migration during embryonic development, focusing on a specific group of muscle precursor cells in fruit flies. By examining how these cells respond to various signaling cues, the study aims to uncover the complex interactions that guide their movement and survival. The researchers will utilize advanced biological models to analyze the role of different signaling pathways, particularly the FGF signaling pathway, in directing cell behavior. This work could provide insights into the processes that, when disrupted, can lead to developmental issues or diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or developmental disorders linked to cell migration and survival issues.
Not a fit: Patients with conditions unrelated to cell migration or embryonic development may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental disorders and potential therapeutic strategies for conditions related to abnormal cell migration and survival.
How similar studies have performed: Previous research has shown success in understanding cell migration and signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Stathopoulos, Angelike — California Institute of Technology
- Study coordinator: Stathopoulos, Angelike
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.