Understanding how cells move and shape during development
Morphogenesis: Biophysics and Genetics of Dorsal Closure
This study looks at how cells work together to form important structures in the body, like the heart and palate, by observing fruit flies, which can help us understand how to improve healing and prevent developmental issues.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10894159 on NIH RePORTER |
What this research studies
This research investigates the processes involved in cell sheet morphogenesis, which is crucial for the development and healing of tissues in animals. By studying the dorsal closure in fruit flies, the researchers aim to uncover the molecular mechanisms that guide how cells interact and move to form structures like the heart and palate. The approach combines live imaging and genetic techniques to analyze how these processes work in both normal and mutant embryos, providing insights into the fundamental biology of cell movement. This work could lead to a better understanding of developmental defects and wound healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with congenital defects related to tissue formation or those interested in advancements in regenerative medicine.
Not a fit: Patients with conditions unrelated to developmental biology or wound healing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating developmental disorders and improving wound healing in patients.
How similar studies have performed: Previous research has shown success in using model organisms like Drosophila to understand complex biological processes, indicating that this approach is both valid and promising.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Kiehart, Daniel Peter — Duke University
- Study coordinator: Kiehart, Daniel Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.