Understanding how cells move and position their nuclei during migration
Cytoskeleton, Nucleus and Integrin Recycling in Cell Migration
This study is exploring how cells move around in the body, which is important for healing wounds and fighting infections, by looking at how the cell's nucleus is positioned and how it sticks to its surroundings, with the hope of improving our understanding of health issues related to cell movement.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10824327 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind cell migration, which is crucial for processes like tissue formation, wound healing, and immune responses. It focuses on two key aspects: how the nucleus is positioned within the cell and how integrins, which help cells adhere to their environment, are recycled. By using advanced techniques to measure forces on the nucleus and studying the interactions between the cytoskeleton and the nucleus, the research aims to fill existing knowledge gaps in cell migration. This could lead to a better understanding of various health conditions related to cell movement.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve altered cell migration, such as cancer patients or those with chronic inflammatory diseases.
Not a fit: Patients with stable conditions unrelated to cell migration or those not experiencing any cellular movement disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to abnormal cell migration, such as cancer metastasis and chronic wounds.
How similar studies have performed: Previous research has shown success in understanding cell migration mechanisms, but this specific focus on nuclear positioning and integrin recycling is relatively novel.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Gundersen, Gregg G — Columbia University Health Sciences
- Study coordinator: Gundersen, Gregg G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.