Understanding How Cells Move and Organize in Tissues
Molecular Regulation of Radial Intercalation
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY · NIH-11000321
This research explores how cells move and organize themselves within tissues, a process vital for healing, immune responses, and understanding conditions like cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11000321 on ClinicalTrials.gov |
What this research studies
This research looks at how cells move in a directed way and break through barriers in tissues, which is a key process in many body functions. We are learning about the tiny internal structures of cells, called microtubules, and how they help cells push through tight spaces. Using a model system, we can watch and measure how cells move and insert themselves into the outer layers of tissue. The goal is to uncover the detailed ways these cell movements are controlled at a molecular level, which could help us better understand how tissues form, heal, and how diseases like cancer spread.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this work might benefit individuals with conditions related to tissue repair, immune function, or cancer.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science research.
Why it matters
Potential benefit: Understanding how cells move and break through tissue barriers could lead to new ways to treat conditions involving tissue repair, immune responses, and cancer progression.
How similar studies have performed: While cell migration is a well-studied area, this specific approach using Xenopus embryos to detail microtubule dynamics during radial intercalation offers a novel perspective on breaking through epithelial barriers.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MITCHELL, BRIAN JOSEPH — NORTHWESTERN UNIVERSITY
- Study coordinator: MITCHELL, BRIAN JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.