Understanding how cells move and develop during embryonic growth
Official title: Uncovering spatio-temporal, mechano-transcriptomic signatures of development
Funded at Columbia Univ New York Morningside · NIH-11024574 · Data updated 2026-11-12
This study is looking at how genes, the shape of cells, and physical forces work together during the early stages of development, which could help us understand how cells move and organize properly, and what might go wrong in that process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $393,093 |
| NIH project number | 1R35GM157082-01 |
| Project ID | NIH-11024574 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with a history of congenital abnormalities or developmental disorders.
✕Less likely to help
Patients with fully developed and healthy embryos or those not at risk for developmental defects may not receive benefit from this research.
What this research studies
This research investigates the complex interactions between gene expression, cell shape, and mechanical forces during embryonic development. By analyzing how these factors work together, the study aims to uncover the mechanisms that lead to proper cell movement and organization. The approach involves using advanced machine learning techniques to analyze data from multiple species, focusing on how gene programs influence tissue dynamics. This could provide insights into developmental processes and potential defects.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of developmental defects in embryos.
How similar studies have gone: Other research has shown success in understanding developmental processes through similar integrative approaches, indicating a promising avenue for further exploration.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Dumitrascu, Bianca — Columbia Univ New York Morningside
- Study coordinator: Dumitrascu, Bianca
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.