Understanding how cells manage stress and protein balance
Official title: Stress Response Pathways Regulating Protein Homeostasis
Funded at Stanford University · NIH-11074034 · Data updated 2026-11-12
This study is looking at how our cells handle stress when they make proteins, which is really important for staying healthy, especially as we age or when we're sick, and it aims to find out how cells fix problems with protein production to help them survive better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $547,978 |
| NIH project number | 5R35GM153301-02 |
| Project ID | NIH-11074034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related conditions or diseases characterized by protein misfolding or stress responses.
✕Less likely to help
Patients with conditions unrelated to cellular stress responses or protein homeostasis may not benefit from this research.
What this research studies
This research investigates the cellular stress response pathways that help cells maintain protein homeostasis, which is crucial for survival and is often disrupted in diseases and aging. The team will explore how cells detect and respond to faulty protein production and examine a unique process called Ribosome-associated Quality Control (RQC). They will also study how cells adapt to stress at a biophysical level, focusing on the regulation of biomolecule movement. By combining molecular and biophysical approaches, the research aims to uncover fundamental insights into cell survival and the biology of diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cell survival and treating diseases related to protein mismanagement.
How similar studies have gone: Previous research has shown promising results in understanding cellular stress responses, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Brandman, Onn — Stanford University
- Study coordinator: Brandman, Onn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.