Understanding how cells manage protein production in health and disease
Regulation of ribosome collisions during health, development and disease
This work explores how cells handle problems during protein creation, which could help us understand conditions like Charcot Marie Disorder.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-11088255 on NIH RePORTER |
What this research studies
Our cells constantly make proteins, and sometimes the machinery, called ribosomes, can get stuck or 'collide' on the genetic instructions. When ribosomes collide, the cell has a special cleanup crew, called the Ribosome Quality Control (RQC) pathway, and a stress response system, called ISR, to fix the problem or remove damaged parts. We are learning how these systems work together to keep cells healthy and how their malfunction might contribute to brain and nerve conditions. By understanding these basic cellular processes, we hope to uncover new ways to address diseases where these systems go awry.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but is relevant to individuals with neurodevelopmental and neurodegenerative conditions, including Charcot Marie Disorder.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could reveal fundamental mechanisms behind neurodegenerative diseases, potentially leading to new targets for future treatments.
How similar studies have performed: The researchers have already developed a new technique, Disome-seq, to map ribosome collisions, indicating a novel approach building on existing knowledge of cellular stress responses.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Meydan Marks, Fatma Sezen — Vanderbilt University
- Study coordinator: Meydan Marks, Fatma Sezen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.