Understanding how cells manage protein production and degradation during stress
Mechanisms of Translation Regulation During Stress
This study is looking at how cells make and manage proteins, especially when they're under stress, to understand how they keep everything balanced and healthy, which could help find new ways to diagnose and treat diseases related to aging and brain health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10876953 on NIH RePORTER |
What this research studies
This research investigates the complex interactions between protein synthesis, quality control, and degradation in cells, particularly during stressful conditions. By examining how these processes communicate, the study aims to uncover mechanisms that help maintain protein balance, known as proteostasis, which is crucial for cell survival and function. The research focuses on the role of protein quality control factors and their collaboration with the machinery that synthesizes proteins. Insights gained could lead to new diagnostic and therapeutic strategies for various diseases, especially those related to aging and neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related conditions or neurodegenerative diseases, as well as those with genetic disorders linked to proteostasis.
Not a fit: Patients with acute, non-degenerative conditions or those unrelated to protein synthesis and degradation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for age-related diseases and improve overall health by enhancing our understanding of protein management in cells.
How similar studies have performed: Previous research has shown promising results in understanding protein homeostasis and its implications for health, indicating that this approach has potential for significant advancements.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Moon, Stephanie Lynn — University of Michigan at Ann Arbor
- Study coordinator: Moon, Stephanie Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.