Understanding how cells manage protein degradation under stress
Official title: Proteasome homeostasis and substrate prioritization
Funded at University of Kansas Medical Center · NIH-10929292 · Data updated 2026-11-12
This study is looking at how our cells manage to break down damaged proteins when they’re under stress, like from heat or other challenges, and it aims to understand how this process changes as we age or when we have diseases like cancer or neurodegenerative disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $387,500 |
| NIH project number | 5R35GM149314-02 |
| Project ID | NIH-10929292 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing age-related conditions or neurodegenerative diseases.
✕Less likely to help
Patients with acute, non-degenerative conditions unrelated to proteasome function may not benefit from this research.
What this research studies
This research investigates how cells adjust their proteasome capacity to degrade proteins when faced with stressors like heat or oxidative stress. By examining the mechanisms behind proteasome regulation and assembly, the study aims to uncover how these processes are affected by aging and diseases such as neurodegenerative disorders and cancer. The research will utilize various cellular models to explore the responses of proteasomes to different stress conditions, providing insights into their role in maintaining cellular health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cellular function and resilience in aging and disease.
How similar studies have gone: Previous research has shown promising results in understanding proteasome function in stress responses, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of Kansas Medical Center
Kansas City, United States Active
Researchers
- Principal investigator: Roelofs, Jeroen — University of Kansas Medical Center
- Study coordinator: Roelofs, Jeroen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.