Understanding how cells manage protein degradation under stress
Proteasome homeostasis and substrate prioritization
['FUNDING_OTHER'] · UNIVERSITY OF KANSAS MEDICAL CENTER · NIH-10929292
This study is looking at how our cells manage to break down damaged proteins when they’re under stress, like from heat or other challenges, and it aims to understand how this process changes as we age or when we have diseases like cancer or neurodegenerative disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KANSAS MEDICAL CENTER (nih funded) |
| Locations | 1 site (KANSAS CITY, UNITED STATES) |
| Trial ID | NIH-10929292 on ClinicalTrials.gov |
What this research studies
This research investigates how cells adjust their proteasome capacity to degrade proteins when faced with stressors like heat or oxidative stress. By examining the mechanisms behind proteasome regulation and assembly, the study aims to uncover how these processes are affected by aging and diseases such as neurodegenerative disorders and cancer. The research will utilize various cellular models to explore the responses of proteasomes to different stress conditions, providing insights into their role in maintaining cellular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related conditions or neurodegenerative diseases.
Not a fit: Patients with acute, non-degenerative conditions unrelated to proteasome function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cellular function and resilience in aging and disease.
How similar studies have performed: Previous research has shown promising results in understanding proteasome function in stress responses, indicating that this approach has potential for significant findings.
Where this research is happening
KANSAS CITY, UNITED STATES
- UNIVERSITY OF KANSAS MEDICAL CENTER — KANSAS CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROELOFS, JEROEN — UNIVERSITY OF KANSAS MEDICAL CENTER
- Study coordinator: ROELOFS, JEROEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers