Understanding how cells manage protein breakdown and recycling.
Official title: Deciphering Novel Principles of Rapid Proteostatic Control and Innovating Spatiotemporal Lysosomal Tools
Funded at University of California-Irvine · NIH-11022697 · Data updated 2026-11-12
This study looks at how our cells clean up and manage proteins, especially focusing on a special process that helps get rid of damaged proteins, which could help us find new ways to treat diseases caused by protein problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $380,540 |
| NIH project number | 1R35GM157370-01 |
| Project ID | NIH-11022697 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diseases linked to protein degradation and homeostasis, such as neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to protein degradation mechanisms may not benefit from this research.
What this research studies
This research investigates the mechanisms by which lysosomes, the cell's waste disposal system, maintain protein balance by breaking down abnormal proteins. It focuses on how certain protein modifications, particularly arginine methylation, facilitate the delivery of proteins to lysosomes for degradation. By exploring the specific protein substrates and the signals that trigger their transport to lysosomes, the research aims to uncover new insights into cellular homeostasis and responses to environmental changes. Patients may benefit from a better understanding of these processes, which could lead to new treatments for diseases related to protein mismanagement.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies for conditions caused by protein mismanagement, improving patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding lysosomal functions and their role in protein degradation, indicating that this approach has potential for success.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Albrecht, Lauren Veronica — University of California-Irvine
- Study coordinator: Albrecht, Lauren Veronica
Related research
Other NIH-funded projects on the same topics.
-
Retinal cell grafts to restore sight in AMD and RP
A patient-focused program aims to replace damaged retinal cells with organized, transplant-ready sheets created from stem cells to improve vision in age-related macular degeneration and related diseases.
-
Treg-based tolerance to dystrophin immune responses in Duchenne muscular dystrophy
A new grant aims to help people with Duchenne muscular dystrophy by teaching the immune system to tolerate the dystrophin treatment delivered by gene therapy.
-
Immune and NGF factors in Alzheimer’s for adults with Down syndrome
This grant studies why people with Down syndrome develop Alzheimer’s disease by looking at immune signals and nerve growth factor problems.
-
Promoting Heart Cell Maturation with Light-Activated Engineered Peptides
Aims to help grown heart cells from stem cells mature more like real adult heart tissue using special peptide coatings that respond to light.
-
Understanding how heart nerves affect dangerous heart rhythms after a heart attack
This NIH grant studies how changes in the heart’s nerve signaling after a heart attack lead to dangerous rhythm problems, with the goal of finding ways to prevent them.
-
All of Us Southern California Consortium supports broad participation in a national health data program
A national health data program in Southern California works to recruit and retain adults to share health information and participate in research that uses this data.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.