Understanding how cells manage misfolded proteins in kidney cells
Mechanisms of ER-Protein Quality Control in Podocytes
['FUNDING_R01'] · UNIVERSITY OF VIRGINIA · NIH-10993170
This study looks at how certain kidney cells handle misfolded proteins to keep your kidneys healthy, and it hopes to find new ways to improve treatments for kidney diseases that happen when proteins don’t fold correctly.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10993170 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which kidney cells, specifically podocytes, manage misfolded proteins through a process called ER-associated degradation (ERAD). The study aims to understand how the SEL1L-HRD1 protein complex helps maintain kidney function by ensuring proper protein folding and degradation. By examining the interactions between ERAD and autophagy, the research seeks to uncover new insights into cellular health and kidney filtration processes. Patients may benefit from findings that could lead to improved treatments for kidney diseases related to protein misfolding.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with kidney diseases, particularly those related to protein misfolding, across all age groups.
Not a fit: Patients with kidney conditions unrelated to protein misfolding may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for kidney diseases caused by protein misfolding.
How similar studies have performed: Other research has shown promising results in understanding protein quality control mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QI, LING — UNIVERSITY OF VIRGINIA
- Study coordinator: QI, LING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.