Understanding how cells manage misfolded membrane proteins
ER and post-ER quality control of integral membrane proteins
This study looks at how our cells deal with proteins that don't fold correctly, which can cause health problems, and it aims to find new ways to help people with these issues by understanding how proteins are fixed or removed in our cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11093971 on NIH RePORTER |
What this research studies
This research investigates the processes by which cells handle misfolded integral membrane proteins, which are crucial for various cellular functions. It focuses on the endoplasmic reticulum (ER) and its role in protein folding and degradation, particularly through a mechanism known as ER-associated degradation (ERAD). By studying how proteins fold and how misfolded proteins are identified and removed, the research aims to uncover the underlying causes of diseases linked to protein misfolding. Patients may benefit from insights gained into these processes, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases associated with misfolded proteins.
Not a fit: Patients with conditions unrelated to protein folding or degradation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases caused by protein misfolding.
How similar studies have performed: Previous research has shown success in understanding protein folding and degradation mechanisms, indicating that this approach is promising.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Brodsky, Jeffrey L. — University of Pittsburgh at Pittsburgh
- Study coordinator: Brodsky, Jeffrey L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.