Understanding how cells manage faulty RNA through a specific decay process
Official title: Decoding Mechanisms of Nonsense-mediated mRNA Decay through Alternative Splicing
Funded at Univ of Arkansas for Med Scis · NIH-11134473 · Data updated 2026-11-12
This study is looking at how our cells manage gene expression and why some genes behave differently in certain tissues or diseases, which could help us find better treatments for conditions related to RNA processing mistakes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | July 8, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $376,670 |
| NIH project number | 5R35GM154991-02 |
| Project ID | NIH-11134473 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to dysregulated gene expression, such as certain cancers, cardiac dysfunction, or diabetes.
✕Less likely to help
Patients with conditions unrelated to RNA processing or gene expression regulation may not benefit from this research.
What this research studies
This research investigates the mechanisms behind nonsense-mediated mRNA decay (NMD) and its relationship with alternative splicing in human cells. By examining how cells regulate gene expression through these processes, the study aims to uncover why certain genes are affected in specific tissues or diseases. The approach involves analyzing biological models to understand the implications of dysregulated NMD in various health conditions. This could lead to new insights into the treatment of diseases linked to RNA processing errors.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for diseases caused by RNA processing errors.
How similar studies have gone: Previous research has shown promising results in understanding RNA processing mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of Arkansas for Med Scis
Little Rock, United States Active
Researchers
- Principal investigator: Rahman, Mohammad Alinoor — Univ of Arkansas for Med Scis
- Study coordinator: Rahman, Mohammad Alinoor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.