Understanding how cells manage energy in health and disease
Mitochondrial metabolite compartmentalization in health and disease
['FUNDING_OTHER'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-10883671
This research explores how our cells organize and use energy, particularly within mitochondria, to better understand metabolic conditions like obesity and diabetes.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10883671 on ClinicalTrials.gov |
What this research studies
Our bodies' cells carefully store and use energy molecules, called metabolites, in different compartments, especially within mitochondria. This organized system allows our bodies to adapt well to various challenges and maintain health. However, when this process goes wrong, it can contribute to metabolic conditions like obesity, insulin resistance, and diabetes. A crucial part of this system involves special proteins called mitochondrial transporters, which move energy molecules in and out of mitochondria. Many of these transporters are still unknown, so this project is creating new tools to identify their specific roles, using brown fat cells as a model.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation but aims to understand the underlying mechanisms of metabolic diseases.
Not a fit: Patients seeking immediate clinical treatments or those without metabolic disorders may not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this basic understanding could pave the way for new treatments for metabolic disorders such as obesity, insulin resistance, and diabetes.
How similar studies have performed: This project is developing a novel experimental platform to overcome previous challenges in studying mitochondrial transporters, making its specific approach largely untested.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KAJIMURA, SHINGO — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: KAJIMURA, SHINGO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.