Understanding how cells manage DNA replication and repair
Regulation of genome replication, recombination, and stress response
This study is looking at how our cells keep their DNA safe and working properly, especially when things go wrong during the process of copying DNA, and it's for anyone interested in understanding how our bodies handle DNA damage and maintain healthy genes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11142774 on NIH RePORTER |
What this research studies
This research investigates the complex processes involved in maintaining genome stability, focusing on DNA replication, repair, and the cellular response to DNA damage. By employing multi-disciplinary approaches, the team aims to uncover how various regulators influence the function of the replisome, the molecular machine responsible for DNA replication. The study also explores how cells cope with challenges that can stall replication forks, particularly in regions of the genome that are prone to stress. Through these investigations, the research seeks to enhance our understanding of critical mechanisms that ensure the integrity of genetic material.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancers or genetic disorders related to DNA repair mechanisms.
Not a fit: Patients with conditions unrelated to DNA replication or repair may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for treating cancers and other diseases linked to DNA damage and instability.
How similar studies have performed: Previous research has shown success in understanding DNA repair mechanisms, indicating that this approach has the potential for meaningful advancements.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Zhao, Xiaolan — Sloan-Kettering Inst Can Research
- Study coordinator: Zhao, Xiaolan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.