Understanding how cells manage DNA replication and repair
Regulation of genome replication, recombination, and stress response
This study is looking at how our cells keep their DNA safe and working properly, especially when things go wrong during the copying process, and it aims to help us understand better ways to prevent diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10928725 on NIH RePORTER |
What this research studies
This research investigates the complex processes involved in maintaining genome stability, focusing on DNA replication, repair, and the cellular response to DNA damage. By employing multi-disciplinary approaches, the team aims to uncover how various regulators interact with the replisome and manage replication forks, especially when faced with obstacles. The study will explore the mechanisms that cells use to stabilize stalled replication forks and how they repair any resulting DNA damage. This research could lead to a deeper understanding of critical strategies for genome regulation, which is essential for preventing diseases like cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of cancer or those diagnosed with conditions related to DNA repair deficiencies.
Not a fit: Patients with non-genetic forms of cancer or those whose conditions are unrelated to DNA replication and repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cancers by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, indicating that this approach has the potential for significant breakthroughs.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Zhao, Xiaolan — Sloan-Kettering Inst Can Research
- Study coordinator: Zhao, Xiaolan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.