Understanding how cells manage DNA damage to prevent cancer
The role of DNA damage tolerance pathways in human cells
This study is looking at how our cells fix DNA damage to help prevent cancer, focusing on a special enzyme called PRIMPOL that helps cells get past problems during DNA copying, and the findings could lead to better treatments and ways to prevent cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11128215 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that human cells use to tolerate and repair DNA damage, which is crucial for maintaining genomic stability and preventing cancer. The focus is on how cells restart stalled DNA replication forks, particularly through the action of the PRIMPOL enzyme, which helps to bypass DNA lesions. By studying the formation and repair of single-stranded DNA gaps that can lead to harmful double-strand breaks, the research aims to uncover new insights into cellular responses to genotoxic agents like cisplatin. This knowledge could ultimately inform better cancer therapies and prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with BRCA mutations or those who are DNA repair-deficient, as they may benefit from insights into their specific vulnerabilities to cancer.
Not a fit: Patients without any genetic predisposition to DNA repair deficiencies or those not affected by cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments and prevention strategies by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Other research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has potential for significant advancements in cancer treatment.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Moldovan, George Lucian — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Moldovan, George Lucian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.