Understanding how cells maintain their shape and function
Official title: The Cytoskeletal Drivers of Cell Polarity
Funded at State University of New York at Buffalo · NIH-11018910 · Data updated 2026-11-12
This study is looking at how cells organize themselves to work properly, which is really important for things like growth and movement, and it hopes to find out how problems with this organization might lead to diseases like cancer and brain disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | December 17, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $379,061 |
| NIH project number | 1R35GM156870-01 |
| Project ID | NIH-11018910 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions linked to cell polarity disruption, such as certain types of cancer or neurological disorders.
✕Less likely to help
Patients with conditions unrelated to cell polarity or those who do not have a diagnosis of cancer or neurological disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms that allow cells to establish and maintain their polarity, which is crucial for their proper function and development. It focuses on the role of cytoskeletal structures and signaling pathways in creating distinct regions within cells that are necessary for processes like cell division and movement. By studying how these components interact and are regulated, the research aims to uncover the underlying causes of diseases that arise from disrupted cell polarity, such as cancer and neurological disorders.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating diseases related to cell polarity, including various cancers and neurological conditions.
How similar studies have gone: Previous research has shown success in understanding cell polarity and its implications in diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Lombardo, Andrew Thomas — State University of New York at Buffalo
- Study coordinator: Lombardo, Andrew Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.