Understanding how cells maintain their membrane structure and function
Mechanisms of membrane homeostasis through protein and lipid transport
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY · NIH-11000780
This study looks at how certain proteins and fats in our cells help keep cell membranes organized, which is important for things like signaling and blood clotting, and it aims to find out how this knowledge could help people with conditions like diabetes and heart disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-11000780 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which eukaryotic cells maintain the composition and organization of their membranes, which is essential for normal cell function. It focuses on the role of specific proteins and lipids in establishing membrane asymmetry, a critical feature that influences various cellular processes such as signaling, blood clotting, and cell fusion. By studying the function of P4-ATPases, which transport lipids across the membrane, the research aims to uncover how these processes are linked to diseases like obesity-related diabetes and cardiovascular disorders. Patients may benefit from insights gained into how membrane dynamics affect health and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with obesity-related type 2 diabetes, cardiovascular diseases, or other conditions linked to membrane transport dysfunction.
Not a fit: Patients with conditions unrelated to membrane transport or those who do not have metabolic or cardiovascular disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for conditions like diabetes and cardiovascular diseases.
How similar studies have performed: Other research has shown promising results in understanding membrane dynamics and their implications for various diseases, suggesting that this approach has potential for significant breakthroughs.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GRAHAM, TODD R — VANDERBILT UNIVERSITY
- Study coordinator: GRAHAM, TODD R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus