Understanding how cells maintain their health and function
Official title: Decipher the Organization of a Multilayered Cellular Quality Control Network
Funded at Southern Methodist University · NIH-11092329 · Data updated 2026-11-12
This study is looking at how our cells fix themselves when they get damaged, especially during stressful times, to help us understand why certain diseases happen and how we might treat them better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Methodist University NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $361,467 |
| NIH project number | 5R35GM150190-03 |
| Project ID | NIH-11092329 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diseases linked to cellular stress and dysfunction.
✕Less likely to help
Patients with conditions unrelated to cellular quality control mechanisms may not benefit from this research.
What this research studies
This research investigates the cellular quality control mechanisms that help maintain the integrity of cells by monitoring and repairing damage to biomacromolecules. It aims to uncover how different quality control pathways interact in response to cellular stress and how their dysfunction can lead to various human diseases. By studying these pathways, the research seeks to provide insights into the underlying causes of diseases linked to cellular stress and potential interventions. Patients may benefit from a better understanding of disease mechanisms and new therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases caused by cellular dysfunction.
How similar studies have gone: While the study of individual quality control pathways has been common, this research aims to explore their interactions, which is a relatively novel approach.
Where this research is happening
-
Southern Methodist University
Dallas, United States Active
Researchers
- Principal investigator: Wu, Zhihao — Southern Methodist University
- Study coordinator: Wu, Zhihao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.