Understanding how cells maintain their genetic integrity during cell division
Mitotic transmission of acentric chromosome fragments
This study looks at how our cells protect their DNA during important stages of cell division, which could help us understand how cancer cells avoid these safety measures, ultimately leading to better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-11014459 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that eukaryotic cells use to ensure their genetic material remains intact during the critical phases of cell division known as anaphase and telophase. By focusing on the abscission checkpoint and other adaptive mechanisms, the study aims to uncover how cells respond to DNA damage and prevent the propagation of errors. The research employs advanced techniques, including fluorescence microscopy, to observe these processes in action. Patients may benefit from insights gained into how cancer cells might evade these safeguards, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may involve genomic instability or those interested in the underlying mechanisms of cell division.
Not a fit: Patients with conditions unrelated to cell division or genomic integrity may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cancer treatments by enhancing our understanding of how cells protect their DNA during division.
How similar studies have performed: Other research has shown success in understanding cell cycle checkpoints, but the specific focus on the abscission checkpoint represents a novel approach.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Sullivan, William T. — University of California Santa Cruz
- Study coordinator: Sullivan, William T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.