Understanding how cells maintain their genetic information during division
Official title: Regulated assembly and function of macromolecular complexes in genome maintenance
Funded at University of California, San Diego · NIH-11012008 · Data updated 2026-11-12
This study looks at how cells make sure their genetic material is copied correctly when they divide, which is important for preventing genetic disorders and cancers, and it hopes to find ways to help patients by understanding these processes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $254,919 |
| NIH project number | 1R35GM156288-01 |
| Project ID | NIH-11012008 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to aneuploidy or chromosomal abnormalities.
✕Less likely to help
Patients with stable genetic conditions that do not involve chromosomal abnormalities may not benefit from this research.
What this research studies
This research investigates the mechanisms that ensure accurate copying and distribution of genetic material when cells divide. It focuses on how specific proteins and enzymes regulate the assembly and function of complexes responsible for DNA replication and chromosome segregation. By studying these processes, the research aims to uncover how errors in these mechanisms can lead to genetic disorders and cancers. Patients may benefit from insights gained into how to prevent or treat conditions related to chromosomal abnormalities.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers and genetic disorders caused by chromosomal errors.
How similar studies have gone: Other research has shown success in understanding chromosomal behavior and its implications for cancer, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Zhou, Huilin — University of California, San Diego
- Study coordinator: Zhou, Huilin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.