Understanding how cells maintain their DNA stability
Official title: Structural basis of eukaryotic clamp loading
Funded at Sloan-Kettering Inst Can Research · NIH-11044040 · Data updated 2026-11-12
This study is looking at how certain proteins help keep our DNA safe and stable when cells divide, which is important for preventing diseases like cancer, and it's for anyone interested in understanding how our bodies repair and copy DNA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $654,396 |
| NIH project number | 5R01ES036297-02 |
| Project ID | NIH-11044040 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic predispositions to cancers or those interested in understanding cellular mechanisms related to DNA stability.
✕Less likely to help
Patients with conditions unrelated to DNA repair or cellular stability may not benefit from this research.
What this research studies
This research investigates the mechanisms by which cells ensure the stability of their DNA across generations, focusing on the role of specific protein complexes known as DNA sliding clamps. These clamps are essential for repairing DNA damage and accurately duplicating chromosomes before cell division. By utilizing advanced techniques like cryogenic electron microscopy, the researchers aim to uncover the structural details of how these clamps interact with DNA and the proteins involved in DNA repair and replication. This knowledge could lead to a better understanding of cellular processes that are crucial for preventing diseases such as cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing DNA repair mechanisms, potentially reducing the risk of cancer and other genetic disorders.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, indicating that this approach has the potential for significant advancements.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Remus, Dirk — Sloan-Kettering Inst Can Research
- Study coordinator: Remus, Dirk
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.