Understanding How Cells Maintain Peroxisomes
Investigating the mechanisms of peroxisome homeostasis
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA SANTA BARBARA · NIH-11110317
This project aims to understand how cells build and maintain tiny compartments called peroxisomes, which are important for our health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA SANTA BARBARA (nih funded) |
| Locations | 1 site (SANTA BARBARA, UNITED STATES) |
| Trial ID | NIH-11110317 on ClinicalTrials.gov |
What this research studies
Our cells contain small compartments called peroxisomes that perform vital metabolic jobs. This project explores how cells create and keep these peroxisomes in good working order, as problems with them can lead to serious genetic conditions and issues related to aging. We are focusing on specific proteins, like Pex1/Pex6, which are crucial for peroxisome function and are often mutated in diseases. By studying these proteins in detail, including how they work in human cells with disease-causing changes, we hope to uncover the basic cellular processes that go wrong.
Who could benefit from this research
Good fit: Patients with rare genetic Peroxisome Biogenesis Disorders (PBDs) or those experiencing age-related conditions linked to peroxisome dysfunction might eventually benefit from this foundational research.
Not a fit: Patients without conditions related to peroxisome function or those seeking immediate treatment options may not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of peroxisome-related diseases and potentially new ways to help patients with these conditions.
How similar studies have performed: While the general area of peroxisome biology has been studied, this project aims to resolve specific molecular mechanisms of Pex proteins, which is a novel and detailed approach.
Where this research is happening
SANTA BARBARA, UNITED STATES
- UNIVERSITY OF CALIFORNIA SANTA BARBARA — SANTA BARBARA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARDNER, BROOKE MEGHAN — UNIVERSITY OF CALIFORNIA SANTA BARBARA
- Study coordinator: GARDNER, BROOKE MEGHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Diseases