Understanding how cells maintain peroxisomes
Investigating the mechanisms of peroxisome homeostasis
This study is looking at how certain proteins help cells build and keep tiny structures called peroxisomes, which are important for our metabolism, and it aims to understand how this knowledge could help with health issues related to genetics and aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Barbara NIH-funded |
| Lab location | 1 site (Santa Barbara, United States) |
| Project ID | NIH-10866442 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which cells create and sustain peroxisomes, which are essential organelles involved in various metabolic processes. The study focuses on the role of specific proteins, known as Pex proteins, in the formation and maintenance of peroxisomes, particularly the AAA-ATPase Pex1/Pex6. By utilizing techniques in protein biochemistry and yeast cell biology, the research aims to uncover the molecular details of how these proteins function and their impact on human health, especially in relation to genetic disorders and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with rare genetic Peroxisome Biogenesis Disorders (PBDs) and those experiencing age-related metabolic issues.
Not a fit: Patients with conditions unrelated to peroxisome function or those without genetic predispositions to PBDs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of peroxisome-related disorders and potential therapeutic strategies for conditions linked to peroxisome dysfunction.
How similar studies have performed: While the specific mechanisms of peroxisome homeostasis are still being explored, previous research has shown promise in understanding related metabolic disorders, indicating potential for success in this area.
Where this research is happening
Santa Barbara, United States
- University of California Santa Barbara — Santa Barbara, United States (Active)
Researchers
- Principal investigator: Gardner, Brooke Meghan — University of California Santa Barbara
- Study coordinator: Gardner, Brooke Meghan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.