Understanding how cells maintain genome stability in health and cancer
Genome Integrity Through the Cell Cycle in Homeostasis and Cancer
This study is looking at how our cells fix DNA damage during cell division to help prevent cancer, especially for people with BRCA1-related cancers, and it hopes to find new ways to improve cancer treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10988283 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that ensure the stability of our DNA during cell division, which is crucial for preventing diseases like cancer. It focuses on how cells respond to DNA damage and the processes involved in repairing this damage. By studying specific proteins, such as 53BP1, the research aims to uncover new insights that could lead to improved cancer therapies, particularly for patients with BRCA1-related cancers. The findings could enhance our understanding of cancer biology and inform the development of targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with BRCA1 mutations or those diagnosed with BRCA1-deficient cancers.
Not a fit: Patients without genetic predispositions to cancer or those with unrelated cancer types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for patients with certain types of cancer, particularly those with genetic predispositions.
How similar studies have performed: Previous research has shown promise in understanding DNA repair mechanisms and their implications for cancer treatment, indicating that this approach is building on established findings.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mirman, Zachary Kenneth — Brigham and Women's Hospital
- Study coordinator: Mirman, Zachary Kenneth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.