Understanding how cells maintain chromosome ends to prevent mutations
Regulation of Telomere Maintenance in Fission Yeast
This study is looking at how certain proteins in fission yeast help keep the ends of chromosomes safe and healthy, which could lead to better treatments for tumors and age-related diseases, helping us understand more about aging and cell growth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10897928 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which eukaryotic cells maintain telomeres, the protective ends of chromosomes, using fission yeast as a model organism. The study focuses on the roles of specific protein complexes that help recruit telomerase and protect telomeres from DNA damage. By exploring how these proteins interact and function, the research aims to uncover insights that could lead to better treatments for tumors and age-related diseases. The findings may also provide a deeper understanding of cellular aging and proliferation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to aging or cancers where telomere dysfunction may play a role.
Not a fit: Patients with conditions unrelated to telomere maintenance or those not experiencing age-related diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for cancers and age-related diseases by enhancing our understanding of telomere maintenance.
How similar studies have performed: Previous research has shown success in understanding telomere maintenance mechanisms in model organisms, indicating that this approach is promising.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Nakamura, Toru — University of Illinois at Chicago
- Study coordinator: Nakamura, Toru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.