Understanding how cells maintain balance through protein regulation and recycling
Official title: Decoding the Ubiquitin and Autophagy Signaling Networks
Funded at Sloan-Kettering Inst Can Research · NIH-11011582 · Data updated 2026-11-12
This study is looking at how two important processes in our cells, called ubiquitin and autophagy, help keep our cells healthy by managing proteins and recycling damaged parts, with the goal of finding new ways to treat diseases that mess with these processes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 3, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $440,000 |
| NIH project number | 1R35GM156454-01 |
| Project ID | NIH-11011582 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to protein misfolding or degradation, such as neurodegenerative diseases.
✕Less likely to help
Patients with conditions unrelated to cellular protein regulation or those who do not have any proteostasis-related disorders may not benefit from this research.
What this research studies
This research investigates the complex networks of ubiquitin and autophagy, which are crucial for maintaining cellular health by regulating protein levels and recycling damaged components. The team will use advanced techniques in biochemistry and cell biology to explore how these processes work and how they can be disrupted in diseases. By identifying key regulatory factors and their roles in cellular responses, the research aims to provide insights that could lead to new therapeutic strategies for conditions related to proteostasis.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diseases caused by protein mismanagement, enhancing patient health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the roles of ubiquitin and autophagy in various diseases, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
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Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Ordureau, Alban — Sloan-Kettering Inst Can Research
- Study coordinator: Ordureau, Alban
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.