Understanding how cells maintain accuracy in protein production
Regulation and Physiological Roles of Translational Fidelity
This study looks at how cells make proteins correctly and what can go wrong when they don’t, especially how things in our environment or our genes can cause mistakes that might lead to problems like bacterial infections or brain issues, and it aims to find out what affects these mistakes so we can better understand how cells react to stress.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-10839347 on NIH RePORTER |
What this research studies
This research investigates how cells ensure the accurate translation of genetic information into proteins, focusing on the quality control mechanisms that prevent errors during this process. It explores how environmental factors and genetic variations can influence the rate of translational errors, which can lead to issues like bacterial growth defects or neurodegeneration in mammals. By utilizing advanced technologies, the research aims to identify conditions that affect translational fidelity at both the population and individual cell levels, providing insights into cellular behavior and responses to stress.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to neurodegeneration or those affected by bacterial infections.
Not a fit: Patients with stable, non-degenerative conditions or those not affected by bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving cellular health and preventing diseases related to protein misfolding and neurodegeneration.
How similar studies have performed: Other research has shown promising results in understanding translational fidelity, but this approach is exploring novel aspects that have not been extensively tested.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Ling, Jiqiang — Univ of Maryland, College Park
- Study coordinator: Ling, Jiqiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.